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I have previously pointed out what appears to me to be certain strong objections to the acceptance of this theory, and defended the views of Angiolella observations which I wish to record in this paper have served only to deepen my conviction that general paralysis depends upon a chronic toxfemia, which produces its effects mainly through implication of cost the vessels of the central nervous system, and that the theory of the premature involution of the nerve-cells is untenable.


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